TESAMORELIN
N-terminally trans-3-hexenoyl-modified analogue of full-length human GHRH(1–44).
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For laboratory research use only. Not for human or veterinary consumption, diagnostic or therapeutic use. Handle in accordance with institutional safety procedures.
Product Overview
Scientific profile
TESAMORELIN is a synthetic 44-amino-acid analogue of human growth-hormone-releasing hormone (GHRH) bearing a trans-3-hexenoyl group on the N-terminal tyrosine. The modification protects the peptide from dipeptidyl-peptidase-4 cleavage while preserving full GHRH-receptor agonism.
Research Background
By stimulating endogenous, pulsatile GH secretion from pituitary somatotrophs, TESAMORELIN raises circulating IGF-1 within the physiological feedback system of the GH axis. It is the active ingredient of an approved pharmaceutical product and has been extensively studied in relation to visceral adipose tissue and hepatic fat.
Areas of Investigation
- GHRH-receptor pharmacology and GH pulsatility
- Visceral adipose tissue and hepatic lipid research
- IGF-1 regulation within the somatotropic axis
- N-terminal acylation as a peptide-stabilisation strategy
Analytical Profile
C-terminally amidated. Purity by reverse-phase HPLC; identity confirmed by ESI-MS. Supplied as a lyophilized peptide.
Specifications
Chemical & physical data
CAS Number
218949-48-5
Molecular Formula
C221H366N72O67S
Molecular Weight
5135.86 g/mol
Physical Form
Lyophilized Powder
Storage Guidelines
-20°C, desiccated and protected from light
Amino Acid Sequence
(3E)-Hex-3-enoyl-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2
44 residues · free base (acetate salt CAS 901758-09-6)
Quality Assurance
Every vial. Every batch. Documented.
Our release process is built for research reproducibility — independent analytics, traceable batches and tamper-evident authentication.
>99% Purity Guaranteed
Every batch must exceed 99% purity by reverse-phase HPLC before it is released to the catalog.
3rd Party Laboratory Tested
Independent analytical labs confirm purity by HPLC and molecular identity by mass spectrometry (MS).
Batch-Tracked Serialization
Each box carries a unique 6-character code linked to its production batch and verifiable online.
Strict Research-Grade Synthesis
Solid-phase synthesis, lyophilization and sealed vialing under controlled, documented conditions.
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