HGH 191AASOMATROPIN
Recombinant 191-amino-acid human growth hormone, identical to the pituitary 22 kDa isoform.
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For laboratory research use only. Not for human or veterinary consumption, diagnostic or therapeutic use. Handle in accordance with institutional safety procedures.
Product Overview
Scientific profile
SOMATROPIN is recombinant human growth hormone (hGH): a 191-amino-acid, single-chain, non-glycosylated protein of approximately 22 kDa whose sequence is identical to the major isoform secreted by the anterior pituitary. The molecule folds into a four-helix bundle stabilised by two disulfide bonds.
Research Background
hGH binds sequentially to two growth-hormone-receptor (GHR) molecules, triggering receptor dimer rearrangement and activation of JAK2 and the STAT5 transcription factor. Downstream effects include hepatic and local induction of insulin-like growth factor-1 (IGF-1) and broad regulation of protein, lipid and carbohydrate metabolism. 4 mg corresponds to approximately 12 IU based on the WHO international standard (≈3 IU per mg).
Areas of Investigation
- GHR / JAK2–STAT5 signal transduction
- IGF-1 induction and the somatotropic axis
- Receptor-binding stoichiometry and protein engineering
- Protein stability, aggregation and formulation studies
Analytical Profile
Purity by reverse-phase / size-exclusion HPLC; identity confirmed by ESI-MS (deconvoluted intact mass). Supplied as a lyophilized protein.
Specifications
Chemical & physical data
CAS Number
12629-01-5
Molecular Formula
C990H1528N262O300S7
Molecular Weight
22124.76 g/mol
Physical Form
Lyophilized Powder
Storage Guidelines
2–8°C or -20°C, desiccated and protected from light
Amino Acid Sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Disulfides: Cys53–Cys165, Cys182–Cys189
Quality Assurance
Every vial. Every batch. Documented.
Our release process is built for research reproducibility — independent analytics, traceable batches and tamper-evident authentication.
>99% Purity Guaranteed
Every batch must exceed 99% purity by reverse-phase HPLC before it is released to the catalog.
3rd Party Laboratory Tested
Independent analytical labs confirm purity by HPLC and molecular identity by mass spectrometry (MS).
Batch-Tracked Serialization
Each box carries a unique 6-character code linked to its production batch and verifiable online.
Strict Research-Grade Synthesis
Solid-phase synthesis, lyophilization and sealed vialing under controlled, documented conditions.
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