SEMAX
Heptapeptide analogue of ACTH(4–7) stabilised with a C-terminal Pro-Gly-Pro motif.
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For laboratory research use only. Not for human or veterinary consumption, diagnostic or therapeutic use. Handle in accordance with institutional safety procedures.
Product Overview
Scientific profile
SEMAX is a synthetic heptapeptide composed of the adrenocorticotropic hormone fragment ACTH(4–7) (Met-Glu-His-Phe) joined to the tripeptide Pro-Gly-Pro, which confers resistance to enzymatic degradation. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and lacks the hormonal (corticotropic) activity of ACTH.
Research Background
Preclinical studies have focused on neurotrophic and neuroprotective effects, including increased expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in rodent hippocampus, and modulation of gene expression following experimental cerebral ischaemia.
Areas of Investigation
- BDNF / TrkB expression and neurotrophin signalling
- Neuroprotection in ischaemia and oxidative-stress models
- Melanocortin-derived peptide structure–activity relationships
- Transcriptomic responses in neural tissue
Analytical Profile
Purity by reverse-phase HPLC; identity confirmed by ESI-MS. Supplied as a lyophilized peptide.
Specifications
Chemical & physical data
CAS Number
80714-61-0
Molecular Formula
C37H51N9O10S
Molecular Weight
813.92 g/mol
Physical Form
Lyophilized Powder
Storage Guidelines
-20°C, desiccated and protected from light
Amino Acid Sequence
H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
Quality Assurance
Every vial. Every batch. Documented.
Our release process is built for research reproducibility — independent analytics, traceable batches and tamper-evident authentication.
>99% Purity Guaranteed
Every batch must exceed 99% purity by reverse-phase HPLC before it is released to the catalog.
3rd Party Laboratory Tested
Independent analytical labs confirm purity by HPLC and molecular identity by mass spectrometry (MS).
Batch-Tracked Serialization
Each box carries a unique 6-character code linked to its production batch and verifiable online.
Strict Research-Grade Synthesis
Solid-phase synthesis, lyophilization and sealed vialing under controlled, documented conditions.
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