TB-500THYMOSIN BETA-4, 43AA
Full-length, N-acetylated 43-residue thymosin β4 — the principal G-actin-sequestering peptide.
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For laboratory research use only. Not for human or veterinary consumption, diagnostic or therapeutic use. Handle in accordance with institutional safety procedures.
Product Overview
Scientific profile
Thymosin β4 (Tβ4) is a highly conserved, 43-amino-acid, N-terminally acetylated peptide present in almost all nucleated cells. It is the major intracellular G-actin-sequestering molecule and regulates the dynamics of actin polymerisation. This product is the full-length 43-residue sequence, not the short LKKTETQ fragment sometimes sold under the same trade name.
Research Background
The central actin-binding domain (LKKTETQ, residues 17–23) mediates interaction with monomeric actin, while the N-terminal tetrapeptide Ac-SDKP is released by prolyl oligopeptidase and has independent biological activity. Tβ4 has been studied extensively in models of cell migration, angiogenesis and tissue repair, including the cardiac-repair work of Bock-Marquette et al. (Nature, 2004).
Areas of Investigation
- Actin cytoskeleton dynamics and cell motility
- Endothelial migration and angiogenesis assays
- Dermal, corneal and cardiac tissue-repair models
- Anti-inflammatory and anti-fibrotic signalling
Analytical Profile
Purity by reverse-phase HPLC; molecular identity confirmed by ESI-MS (deconvoluted mass). Supplied as a lyophilized solid.
Specifications
Chemical & physical data
CAS Number
77591-33-4
Molecular Formula
C212H350N56O78S
Molecular Weight
4963.44 g/mol
Physical Form
Lyophilized Powder
Storage Guidelines
-20°C, desiccated and protected from light
Amino Acid Sequence
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-OH
Actin-binding motif: LKKTETQ (residues 17–23)
Quality Assurance
Every vial. Every batch. Documented.
Our release process is built for research reproducibility — independent analytics, traceable batches and tamper-evident authentication.
>99% Purity Guaranteed
Every batch must exceed 99% purity by reverse-phase HPLC before it is released to the catalog.
3rd Party Laboratory Tested
Independent analytical labs confirm purity by HPLC and molecular identity by mass spectrometry (MS).
Batch-Tracked Serialization
Each box carries a unique 6-character code linked to its production batch and verifiable online.
Strict Research-Grade Synthesis
Solid-phase synthesis, lyophilization and sealed vialing under controlled, documented conditions.
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